Providing a new Dimension of Drug Discovery
BINDING KINETICS IN REAL TIME
01 / VERSATILE
01 / VERSATILE
02 / HIGH THROUGHPUT
03 / QUANTITATIVE
Determine real-time binding kinetics for your protein target of interest and a number of small molecules or biomolecular drugs, including: antibodies, peptides, nanoparticles, nucleic acids, and more. Enhance translatability to the market by utilizing Bindkin Bio's proprietary native protein production system.
Find the experimentally-proven top binders out of your set of hundreds or more lead compound candidates. Get real-time binding kinetics data for up to thousands of compounds per target per day.
Quickly quantify experimental binding kinetics parameters, including affinity, k-on, and k-off for hundreds or more molecules per your target of interest. Direct binding without labels promotes structural integrity for improved accuracy. Utilize this data for further drug design by determining the structure-activity relationships (SAR) between your target and hundreds of compound scaffolds.
MEET BINDKIN BIO
OUR STORY
Our co-founders struggled with difficult-to-isolate drug targets for years before realizing the solution to their drug discovery woes: invent a new approach. While partnering with leaders in AI drug design, our founders discovered the importance of beginning with native protein targets and experimentally validating all predicted drug interactions. We have utilized this approach in other forums to develop a number of molecules that are currently at various stages of clinical development, and we are deeply passionate about helping others in drug discovery do the same.
OUR VISION
By developing a novel approach to drug discovery, we boldly aim to find a cure for every disease. Traditional approaches to drug discovery have exhausted their capacity to identify hard-to-isolate targets. With the burgeoning approaches of computational biology and AI to expedite compound identification, we form alliances with these groups to provide experimental binding data for their lead compounds, thus accelerating the rate at which meaningful discoveries are made.
OUR TECHNOLOGY
Our approach is simple, yet refined. First, we have developed a proprietary protein isolation technique that promotes the likelihood of finding true binders from the very beginning. Next, we perform high-throughput, real-time, experimental binding kinetics assays on a target of interest and hundreds of predicted compounds simultaneously. We determine the affinity, k-on, and k-off binding parameters for all compounds in parallel, allowing our clients to prioritize lead compounds, and providing them physical data for pre-clinical drug packages. Computational biologists may also utilize experimental binding data with native targets to better improve their downstream binding predictions.
EXPERIMENTALLY VALIDATE PREDICTED DRUG BINDERS
EXPERIMENTALLY VALIDATE PREDICTED DRUG BINDERS
We provide binding kinetics data for your drug candidates and target proteins of interest. Our direct binding studies provide high-throughput, experimental measurements of affinity, k-on, and k-off between drug candidates and their targets.
